Symptoms and Causes of Adenocarcinoma

Since adenocarcinoma can affect so many parts of the body, the causes can vary a lot. But here are some common risk factors:

• Smoking. Smoking is the biggest cause of lung adenocarcinoma. Exposure to secondhand smoke also plays a role.
• Genes. Having a family history of a certain kind of cancer can make it more likely you develop it.
• Lifestyle. What we eat or whether we exercise or drink alcohol (and how often) can all play a part in whether we’re more likely to get some kinds of cancers, especially if we already have the genes for them.
• Obesity. Carrying a lot of extra weight can be a risk factor for some cancers.
• Environment. Exposure to harmful toxins in our food, water, air, or products we use can cause adenocarcinoma.
• Radiation exposure. Previous radiation therapy can put you at a higher risk of getting adenocarcinoma. So can too much UV radiation from sunlight.

Adenocarcinoma Symptoms

The symptoms of adenocarcinoma you experience will depend on the type of cancer you have. Here are some of the main cancer symptoms:

Lung cancer

A test called low-dose CT (LDCT) scan is available for people who are smokers or otherwise at higher risk for lung cancer. Symptoms include:

• Persistent cough
• Coughing up blood, even a small amount
• Shortness of breath or wheezing
• Loss of appetite
• Weight loss
• Chest pain
• Repeated infections (such as bronchitis and pneumonia)

Prostate cancer

If you’re having regular prostate exams, this may be caught in the early stages. Otherwise, there may not be any symptoms. In later stages you may experience:

• Frequent peeing (especially at night)
• Trouble fully emptying your bladder
• Weak urine flow
• Blood in the urine
• Pain when sitting down
• Pain or burning when urinating

Breast cancer

If you’re having regular mammograms, your doctor may catch this in the early stages. Some warning signs include:

• Lump in the breast or under the armpit
• Thickening or swelling of the breast
• Irritation or dimpling of the breast skin 
• Red or flaky skin around the nipple
• Nipple discharge other than milk (like blood)
• Breast pain

Pancreatic cancer

There’s no screening test for this and no symptoms in the early stages. In the later stages you might experience:

• Back or belly pain
• Jaundice (yellowing of the skin and whites of eyes)
• Dark or brown urine
• Light or gray stools
• Itching
• Weight loss and loss of appetite

Stomach cancer

Screening tests are available but not given routinely in the U.S., as stomach cancer is not that common. In other parts of the world, stomach cancer screening is routine. If you have a family history of stomach cancer, ask your doctor about a screening test called an upper endoscopy (a tube with a tiny camera is put down your throat). There may be no symptoms of stomach adenocarcinoma in the early stages. In the later stages you may experience: 

• Stomach pain
• Loss of appetite
• Weight loss
• Feeling full after eating small amounts of food
• Heartburn or indigestion
• Nausea or vomiting

Colorectal (colon) cancer

If you have a regular colonoscopy, where a doctor puts a tube into your colon to check for polyps, this may be caught in the early stages. The symptoms you experience will depend on the size of the tumor in the colon but could include:

• Changes to your bowel habits, such as more diarrhea or constipation
• Persistent need to have a bowel movement
• Rectal bleeding or bloody stool 
• Stomach pain, gas, or cramping
• Fatigue and weakness

Esophageal cancer

Screening tests are available but not given routinely in the U.S. as this cancer is not that common. An upper endoscopy is the normal screening test. In the early stages, there may be no symptoms. In later stages, symptoms may include:

• Difficulty swallowing some foods
• Pain or choking with swallowing
• Chest pain or pressure 
• Worsening heartburn or indigestion
• Vomiting
• Coughing or hoarseness
• Weight loss

Adenocarcinoma Diagnosis

Your doctor will give you a physical exam. They may feel your organs to see if there is any swelling or a growth.

They may also notice something’s not right when you have regular screening tests like a colonoscopy or a mammogram.

You may also get tests to see if you have adenocarcinoma in any of your organs:

• Blood tests. Your blood may show signs of cancer. For example, your doctor may check it to see if you have anemia from a bleeding tumor. Also, high levels of some enzymes or other things made by cancer cells might mean cancer is likely.
• Imaging tests. They can help see if any of the tissues in your organs don’t look normal. You may get a CT scan, which is a powerful X-ray that makes detailed pictures inside your body. Or you might need an MRI, which uses powerful magnets and radio waves to make pictures of organs and tissues. If you do have cancer and start treatment, imaging tests can also help your doctor learn how well your treatment is working.
• Biopsy. Your doctor takes a small sample of tissue from the organ where they think you may have cancer. For example, they may remove a polyp or growth from your colon, or use a small needle to remove tissue from your breast. A doctor called a pathologist will look at it under a microscope to see if there are cancer cells. A biopsy can also show if they are just in that one organ, have spread from another place in your body, or how much they’ve grown.

Adenocarcinoma grading

This refers to the grade given to your cancer cells based on what they look like under a microscope, compared with normal cells. If the tumor cells look like normal cells (well-differentiated), they are given a low grade. If they don’t look very much like normal cells (poorly differentiated), they are given a high grade. The higher the grade, the faster the cancer is likely to spread. Grades are usually from 1 to 4, though some may only go from 1 to 3. The grades might also be written in Roman numerals.

• Grade 1. Well-differentiated; cancer cells not growing very fast
• Grade 2. Moderately differentiated; cancer cells growing faster than normal cells
• Grade 3. Poorly differentiated; cancer cells growing and spreading fast
• Grade 4. Undifferentiated; cancer cells growing and spreading fast
• Grade X. Grade is unknown.

Adenocarcinoma staging

This shouldn’t be confused with grading. Grading has to do with the appearance of the cancerous cells, while staging describes the size of the cancer tumor and how far it has spread. There are four stages usually designated as numbers 1 to 4, or as Roman numerals I to IV. The higher the number, the more advanced the cancer is. Each type of cancer has its own staging system, but here is the general rule:

• Stage I. The cancer is small and hasn’t spread beyond the cells where it started.
• Stage II. The cancer is a bit larger than at stage I but hasn’t spread beyond the organ where it started.
• Stage III. The cancer is larger than stage II and may have spread to nearby lymph nodes or other tissues.
• Stage IV. The cancer has spread to at least one other organ (metastasized).

You might see a stage 0 as well. This means there is no cancer but abnormal cells have been found with the potential to become cancerous. These should be treated as well. 

The staging number helps the doctor decide how to treat the cancer. Higher-stage cancers are harder to treat than lower-stage cancers. 

TNM Staging System

This system uses letters to describe the kind of cancer you have:

• T (tumor) describes the size of your tumor, using numbers 1-4 (1 is small; 4 is very large).
• N (nodes) describes how many of your lymph nodes have cancer, using numbers 1-3. (1 means no lymph nodes have cancer; 3 means many do).
• M (metastases) describes whether your cancer has spread to other parts of your body (0 means it has not spread; 1 means it has spread).

You might see your cancer described as (for instance) T2N1M0 in a lab report. If you see an X included (for example T2N1MX), that means that something cannot be measured. In this example, the metastases cannot be measured.

Adenocarcinoma Treatment

Your treatment depends on the type of adenocarcinoma you have and the stage of your cancer.

• Surgery. Your first treatment will probably be to remove the tumor and tissue around it. Your doctor can then look at the tissue to see if you’re cured or if there still may be cancer cells in your body. You may need to combine other treatments with surgery to make sure your cancer is gone.
• Chemotherapy. Drugs can kill adenocarcinoma cells, slow their growth, or even cure your disease. These drugs may kill healthy cells as well.
• Radiation. Doctors use high-energy X-rays or other types of rays to kill your cancer cells.
• Immunotherapy.  This could refer to drugs that block your immune checkpoints (allowing immune cells to respond more strongly to the cancer cells) or to immune cells taken from your tumor, changed in the lab to better fight the cancer cells and reinjected into your body) or other procedures that use your immune system to better fight the cancer.
• Targeted therapy. This uses drugs that target just your cancer cells rather than all your cells. Not all cancers can be treated with targeted therapy.

You may need chemo along with surgery and radiation to treat your cancer. 

Your cancer treatment can have side effects. You might get very tired or feel like you need to throw up. Your doctor can suggest ways to manage these problems. They may prescribe drugs that fight nausea.

Talk to your family and friends about how you’re feeling, and don’t hesitate to ask them for help while you’re getting treatment. Also tell them about your worries and fears. They can be a huge source of support.

Check the web site of the American Cancer Society. You can find out about local support groups, where you’ll meet people who have the same type of cancer as you and can share their experience.

Takeaways

Adenocarcinoma is a very common type of cancer that starts either in the skin or in one of the body cavities. It can affect many parts of your body like your colon, breasts, lungs, pancreas, or prostate. Treatments like surgery, radiation, and chemotherapy can stop or slow down the disease.